2v00: Difference between revisions

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OCA

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-[[Image:2v00.jpg|left|200px]]
+{{Seed}}
+[[Image:2v00.png|left|200px]]
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 {{STRUCTURE_2v00|  PDB=2v00  |  SCENE=  }}
-'''X-RAY CRYSTAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH COMPOUND 1'''
+===X-RAY CRYSTAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH COMPOUND 1===
-==Overview==
+<!--
-Fragment-based lead generation was applied to find novel small-molecule inhibitors of beta-secretase (BACE-1), a key target for the treatment of Alzheimer's disease. Fragment hits coming from a 1D NMR screen were characterized by BIAcore, and the most promising compounds were soaked into protein crystals to help the rational design of more potent hit analogues. Problems arising due to our inability to grow BACE-1 crystals at the biologically relevant pH at which the screen was run were overcome by using endothiapepsin as a surrogate aspartyl protease. Among others, we identified 6-substituted isocytosines as a novel warhead against BACE-1, and the accompanying paper in this journal describes how these were optimized to a lead series of nanomolar inhibitors.1.
+The line below this paragraph, {{ABSTRACT_PUBMED_17985861}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17985861 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17985861}}
 ==About this Structure==
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 [[Category: Surrogate protein]]
 [[Category: Zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:55:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:40:17 2008''