2r6g: Difference between revisions

Revision as of 21:34, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2r6g.png

Template:STRUCTURE 2r6g

The Crystal Structure of the E. coli Maltose TransporterThe Crystal Structure of the E. coli Maltose Transporter

Template:ABSTRACT PUBMED 18033289

About this StructureAbout this Structure

2R6G is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a catalytic intermediate of the maltose transporter., Oldham ML, Khare D, Quiocho FA, Davidson AL, Chen J, Nature. 2007 Nov 22;450(7169):515-21. PMID:18033289

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''The Crystal Structure of the E. coli Maltose Transporter'''
+===The Crystal Structure of the E. coli Maltose Transporter===
-==Overview==
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-The maltose uptake system of Escherichia coli is a well-characterized member of the ATP-binding cassette transporter superfamily. Here we present the 2.8-A crystal structure of the intact maltose transporter in complex with the maltose-binding protein, maltose and ATP. This structure, stabilized by a mutation that prevents ATP hydrolysis, captures the ATP-binding cassette dimer in a closed, ATP-bound conformation. Maltose is occluded within a solvent-filled cavity at the interface of the two transmembrane subunits, about halfway into the lipid bilayer. The binding protein docks onto the entrance of the cavity in an open conformation and serves as a cap to ensure unidirectional translocation of the sugar molecule. These results provide direct evidence for a concerted mechanism of transport in which solute is transferred from the binding protein to the transmembrane subunits when the cassette dimer closes to hydrolyse ATP.
+The line below this paragraph, {{ABSTRACT_PUBMED_18033289}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_18033289}}
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 [[Category: Sugar transport]]
 [[Category: Transmembrane]]
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