2r2f: Difference between revisions

Revision as of 08:20, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2r2f.png

Template:STRUCTURE 2r2f

RIBONUCLEOTIDE REDUCTASE R2F PROTEIN FROM SALMONELLA TYPHIMURIUM (OXIDIZED)RIBONUCLEOTIDE REDUCTASE R2F PROTEIN FROM SALMONELLA TYPHIMURIUM (OXIDIZED)

Template:ABSTRACT PUBMED 9748343

About this StructureAbout this Structure

2R2F is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

ReferenceReference

Structure of Salmonella typhimurium nrdF ribonucleotide reductase in its oxidized and reduced forms., Eriksson M, Jordan A, Eklund H, Biochemistry. 1998 Sep 22;37(38):13359-69. PMID:9748343

Page seeded by OCA on Mon Jul 28 08:19:56 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2r2f.jpg|left|200px]]
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 {{STRUCTURE_2r2f|  PDB=2r2f  |  SCENE=  }}
-'''RIBONUCLEOTIDE REDUCTASE R2F PROTEIN FROM SALMONELLA TYPHIMURIUM (OXIDIZED)'''
+===RIBONUCLEOTIDE REDUCTASE R2F PROTEIN FROM SALMONELLA TYPHIMURIUM (OXIDIZED)===
-==Overview==
+<!--
-The first class Ib ribonucleotide reductase R2 structure, from Salmonella typhimurium, has been determined at 2.0 A resolution. The overall structure is similar to the Escherichia coli class Ia enzyme despite only 23% sequence identity. The most spectacular difference is the absence of the pleated sheet and adjacent parts present in the E. coli R2 structure; the heart-shaped structure loses its tip. From sequence comparisons, it appears that this feature is shared with all other class Ib enzymes and, in this respect, is more like the mammalian class Ia enzymes. Both the oxidized and reduced iron forms have been investigated. In the ferric iron center, both iron ions are octahedrally coordinated and bridged by one carboxylate and one oxide ion. The ferrous form has lost the bridging oxide ion but is bridged by two carboxylates. Accompanying the change in redox state, helix E changes its conformation from one covering the metal center in the oxidized form to a more open reduced form. A narrow channel is opened which may permit easier access of oxygen to the ferrous iron site and to efficiently generate the tyrosyl radical.
+The line below this paragraph, {{ABSTRACT_PUBMED_9748343}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9748343 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9748343}}
 ==About this Structure==
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 [[Category: Nucleotide metabolism]]
 [[Category: Reductase]]
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