2q99: Difference between revisions

Revision as of 11:29, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2q99.png

Template:STRUCTURE 2q99

Crystal Structure of Saccharopine Dehydrogenase from Saccharomyces cerevisiaeCrystal Structure of Saccharopine Dehydrogenase from Saccharomyces cerevisiae

Template:ABSTRACT PUBMED 17854830

About this StructureAbout this Structure

2Q99 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae., Burk DL, Hwang J, Kwok E, Marrone L, Goodfellow V, Dmitrienko GI, Berghuis AM, J Mol Biol. 2007 Oct 26;373(3):745-54. Epub 2007 Aug 24. PMID:17854830

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OCA

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-'''Crystal Structure of Saccharopine Dehydrogenase from Saccharomyces cerevisiae'''
+===Crystal Structure of Saccharopine Dehydrogenase from Saccharomyces cerevisiae===
-==Overview==
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-The 1.64 A structure of the apoenzyme form of saccharopine dehydrogenase (SDH) from Saccharomyces cerevisiae shows the enzyme to be composed of two domains with similar dinucleotide binding folds with a deep cleft at the interface. The structure reveals homology to alanine dehydrogenase, despite low primary sequence similarity. A model of the ternary complex of SDH, NAD, and saccharopine identifies residues Lys77 and Glu122 as potentially important for substrate binding and/or catalysis, consistent with a proton shuttle mechanism. Furthermore, the model suggests that a conformational change is required for catalysis and that residues Lys99 and Asp281 may be instrumental in mediating this change. Analysis of the crystal structure in the context of other homologous enzymes from pathogenic fungi and human sources sheds light into the suitability of SDH as a target for antimicrobial drug development.
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 [[Category: Oxidoreductase]]
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