2q7o: Difference between revisions

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{{STRUCTURE_2q7o|  PDB=2q7o  |  SCENE=  }}  
{{STRUCTURE_2q7o|  PDB=2q7o  |  SCENE=  }}  


'''Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H'''
===Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H===




==Overview==
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Human purine nucleoside phosphorylase (PNP) was crystallized with transition-state analogue inhibitors Immucillin-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry. The inhibitors demonstrate that major driving forces for tight binding of these analogues are the leaving group interaction and the cationic mimicry of the transition state, even though large geometric changes occur with d-Immucillins and l-Immucillins bound to human PNP.
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{{ABSTRACT_PUBMED_18154341}}


==About this Structure==
==About this Structure==
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[[Category: Purine nucleoside phosphorylase]]
[[Category: Purine nucleoside phosphorylase]]
[[Category: Transferase]]
[[Category: Transferase]]
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