2q2t: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2q2t.gif|left|200px]]
+{{Seed}}
+[[Image:2q2t.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2q2t|  PDB=2q2t  |  SCENE=  }}
-'''Structure of Chlorella virus DNA ligase-adenylate bound to a 5' phosphorylated nick'''
+===Structure of Chlorella virus DNA ligase-adenylate bound to a 5' phosphorylated nick===
-==Overview==
+<!--
-Chlorella virus DNA ligase, the smallest eukaryotic ligase known, has pluripotent biological activity and an intrinsic nick-sensing function, despite having none of the accessory domains found in cellular ligases. A 2.3-A crystal structure of the Chlorella virus ligase-AMP intermediate bound to duplex DNA containing a 3'-OH-5'-PO4 nick reveals a new mode of DNA envelopment, in which a short surface loop emanating from the OB domain forms a beta-hairpin 'latch' that inserts into the DNA major groove flanking the nick. A network of interactions with the 3'-OH and 5'-PO4 termini in the active site illuminates the DNA adenylylation mechanism and the crucial roles of AMP in nick sensing and catalysis. Addition of a divalent cation triggered nick sealing in crystallo, establishing that the nick complex is a bona fide intermediate in the DNA repair pathway.
+The line below this paragraph, {{ABSTRACT_PUBMED_17618295}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17618295 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17618295}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Lysine adenylate]]
 [[Category: Protein-dna complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:13:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:27:37 2008''