1ikf: Difference between revisions
New page: left|200px<br /> <applet load="1ikf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ikf, resolution 2.5Å" /> '''A CONFORMATION OF CY... |
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[[Image:1ikf.gif|left|200px]]<br /> | [[Image:1ikf.gif|left|200px]]<br /><applet load="1ikf" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX'''<br /> | '''A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
The conformation of the immunosuppressive drug cyclosporin A (CsA) in a | The conformation of the immunosuppressive drug cyclosporin A (CsA) in a complex with a Fab molecule has been established by crystallographic analysis to 2.65 angstrom resolution. This conformation of CsA is similar to that recently observed in the complex with the rotamase cyclophilin, its binding protein in vivo, and totally different from its conformation in an isolated form as determined from x-ray and nuclear magnetic resonance analysis. Because the surfaces of CsA interacting with cyclophilin or with the Fab are not identical, these results suggest that the conformation of CsA observed in the bound form preexists in aqueous solution and is not produced by interaction with the proteins. | ||
==About this Structure== | ==About this Structure== | ||
1IKF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | 1IKF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IKF OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Altschuh, D.]] | [[Category: Altschuh, D.]] | ||
[[Category: Rees, B.]] | [[Category: Rees, B.]] | ||
[[Category: Thierry, J | [[Category: Thierry, J C.]] | ||
[[Category: Vix, O.]] | [[Category: Vix, O.]] | ||
[[Category: complex (antibidy/immunosuppressant)]] | [[Category: complex (antibidy/immunosuppressant)]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:12:49 2008'' | ||
Revision as of 14:12, 21 February 2008
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A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX
OverviewOverview
The conformation of the immunosuppressive drug cyclosporin A (CsA) in a complex with a Fab molecule has been established by crystallographic analysis to 2.65 angstrom resolution. This conformation of CsA is similar to that recently observed in the complex with the rotamase cyclophilin, its binding protein in vivo, and totally different from its conformation in an isolated form as determined from x-ray and nuclear magnetic resonance analysis. Because the surfaces of CsA interacting with cyclophilin or with the Fab are not identical, these results suggest that the conformation of CsA observed in the bound form preexists in aqueous solution and is not produced by interaction with the proteins.
About this StructureAbout this Structure
1IKF is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex., Altschuh D, Vix O, Rees B, Thierry JC, Science. 1992 Apr 3;256(5053):92-4. PMID:1566062
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