2p9h: Difference between revisions

Revision as of 04:06, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2p9h.png

Template:STRUCTURE 2p9h

High resolution structure of the Lactose Repressor bound to IPTGHigh resolution structure of the Lactose Repressor bound to IPTG

Template:ABSTRACT PUBMED 17543986

About this StructureAbout this Structure

2P9H is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Structural analysis of lac repressor bound to allosteric effectors., Daber R, Stayrook S, Rosenberg A, Lewis M, J Mol Biol. 2007 Jul 20;370(4):609-19. Epub 2007 Apr 19. PMID:17543986

Page seeded by OCA on Mon Jul 28 04:06:13 2008

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OCA

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-'''High resolution structure of the Lactose Repressor bound to IPTG'''
+===High resolution structure of the Lactose Repressor bound to IPTG===
-==Overview==
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-The lac operon is a model system for understanding how effector molecules regulate transcription and are necessary for allosteric transitions. The crystal structures of the lac repressor bound to inducer and anti-inducer molecules provide a model for how these small molecules can modulate repressor function. The structures of the apo repressor and the repressor bound to effector molecules are compared in atomic detail. All effectors examined here bind to the repressor in the same location and are anchored to the repressor through hydrogen bonds to several hydroxyl groups of the sugar ring. Inducer molecules form a more extensive hydrogen-bonding network compared to anti-inducers and neutral effector molecules. The structures of these effector molecules suggest that the O6 hydroxyl on the galactoside is essential for establishing a water-mediated hydrogen bonding network that bridges the N-terminal and C-terminal sub-domains. The altered hydrogen bonding can account in part for the different structural conformations of the repressor, and is vital for the allosteric transition.
+The line below this paragraph, {{ABSTRACT_PUBMED_17543986}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_17543986}}
 ==About this Structure==
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 [[Category: Gene regulation]]
 [[Category: Lac repressor]]
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