2p95: Difference between revisions

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-[[Image:2p95.jpg|left|200px]]
+{{Seed}}
+[[Image:2p95.png|left|200px]]
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 {{STRUCTURE_2p95|  PDB=2p95  |  SCENE=  }}
-'''Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide'''
+===Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide===
-==Overview==
+<!--
-In the search of Factor Xa (FXa) inhibitors structurally different from the pyrazole-based series, we identified a viable series of enantiopure cis-(1R,2S)-cycloalkyldiamine derivatives as potent and selective inhibitors of FXa. Among them, cyclohexyldiamide 7 and cyclopentyldiamide 9 were the most potent neutral compounds, and had good anticoagulant activity comparable to the pyrazole-based analogs. Crystal structures of 7-FXa and 9-FXa illustrate binding similarities and differences between the five- and the six-membered core systems, and provide rationales for the observed SAR of P1 and linker moieties.
+The line below this paragraph, {{ABSTRACT_PUBMED_17588746}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17588746 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17588746}}
 ==About this Structure==
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 [[Category: Protein inhibitor complex]]
 [[Category: Serine protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:38:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:04:43 2008''