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| {{STRUCTURE_2otl| PDB=2otl | SCENE= }} | | {{STRUCTURE_2otl| PDB=2otl | SCENE= }} |
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| '''Girodazole bound to the large subunit of Haloarcula marismortui'''
| | ===Girodazole bound to the large subunit of Haloarcula marismortui=== |
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| ==Overview==
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| Crystal structures of the 50 S ribosomal subunit from Haloarcula marismortui complexed with two antibiotics have identified new sites at which antibiotics interact with the ribosome and inhibit protein synthesis. 13-Deoxytedanolide binds to the E site of the 50 S subunit at the same location as the CCA of tRNA, and thus appears to inhibit protein synthesis by competing with deacylated tRNAs for E site binding. Girodazole binds near the E site region, but is somewhat buried and may inhibit tRNA binding by interfering with conformational changes that occur at the E site. The specificity of 13-deoxytedanolide for eukaryotic ribosomes is explained by its extensive interactions with protein L44e, which is an E site component of archaeal and eukaryotic ribosomes, but not of eubacterial ribosomes. In addition, protein L28, which is unique to the eubacterial E site, overlaps the site occupied by 13-deoxytedanolide, precluding its binding to eubacterial ribosomes. Girodazole is specific for eukarytes and archaea because it makes interactions with L15 that are not possible in eubacteria.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17321546}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17321546 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17321546}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Large subunit]] | | [[Category: Large subunit]] |
| [[Category: Ribosome]] | | [[Category: Ribosome]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:37:47 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:36:09 2008'' |