|
|
| Line 1: |
Line 1: |
| [[Image:2ojt.jpg|left|200px]] | | {{Seed}} |
| | [[Image:2ojt.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_2ojt| PDB=2ojt | SCENE= }} | | {{STRUCTURE_2ojt| PDB=2ojt | SCENE= }} |
|
| |
|
| '''Structure and mechanism of kainate receptor modulation by anions'''
| | ===Structure and mechanism of kainate receptor modulation by anions=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| L-glutamate, the major excitatory neurotransmitter in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which are named AMPA, kainate, and NMDA receptors. In common with many signal transduction proteins, glutamate receptors are modulated by ions and small molecules, including Ca(2+), Mg(2+), Zn(2+), protons, polyamines, and steroids. Strikingly, the activation of kainate receptors by glutamate requires the presence of both Na(+) and Cl(-) in the extracellular solution, and in the absence of these ions, receptor activity is abolished. Here, we identify the site and mechanism of action of anions. Surprisingly, we find that Cl(-) ions are essential structural components of kainate receptors. Cl(-) ions bind in a cavity formed at the interface between subunits in a dimer pair. In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17359918}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17359918 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_17359918}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 24: |
Line 28: |
| [[Category: Mayer, M L.]] | | [[Category: Mayer, M L.]] |
| [[Category: Membrane protein]] | | [[Category: Membrane protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:03:34 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:45:03 2008'' |