2oi4: Difference between revisions

Revision as of 03:18, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2oi4.png

Template:STRUCTURE 2oi4

Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazoleCrystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole

Template:ABSTRACT PUBMED 17406720

About this StructureAbout this Structure

2OI4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand., Pagano N, Maksimoska J, Bregman H, Williams DS, Webster RD, Xue F, Meggers E, Org Biomol Chem. 2007 Apr 21;5(8):1218-27. Epub 2007 Mar 20. PMID:17406720

Page seeded by OCA on Tue Jul 29 03:18:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole'''
+===Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole===
-==Overview==
+<!--
-A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study.
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 ==About this Structure==
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 [[Category: Atp-binding,phosphorylation]]
 [[Category: Transferase,pim1,kinase]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:18:20 2008''