2oah: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2oah.jpg|left|200px]]
+{{Seed}}
+[[Image:2oah.png|left|200px]]
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 {{STRUCTURE_2oah|  PDB=2oah  |  SCENE=  }}
-'''Crystal Structure of Human Beta Secretase Complexed with inhibitor'''
+===Crystal Structure of Human Beta Secretase Complexed with inhibitor===
-==Overview==
+<!--
-A series of low-molecular weight 2,6-diamino-isonicotinamide BACE-1 inhibitors containing an amine transition-state isostere were synthesized and shown to be highly potent in both enzymatic and cell-based assays. These inhibitors contain a trans-S,S-methyl cyclopropane P(3) which bind BACE-1 in a 10s-loop down conformation giving rise to highly potent compounds with favorable molecular weight and moderate to high susceptibility to P-glycoprotein (P-gp) efflux.
+The line below this paragraph, {{ABSTRACT_PUBMED_17257835}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17257835 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17257835}}
 ==About this Structure==
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 [[Category: Bace]]
 [[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:31:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:24:28 2008''