1iod: Difference between revisions

[[Image:1iod.gif|left|200px]]<br />

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The gamma-carboxyglutamic acid (Gla) domain of blood coagulation factors, is responsible for Ca2+-dependent phospholipid membrane binding. Factor, X-binding protein (X-bp), an anticoagulant protein from snake venom, specifically binds to the Gla domain of factor X. The crystal structure of, X-bp in complex with the Gla domain peptide of factor X at 2.3-A, resolution showed that the anticoagulation is based on the fact that two, patches of the Gla domain essential for membrane binding are buried in the, complex formation. The Gla domain thus is expected to be a new target of, anticoagulant drugs, and X-bp provides a basis for designing them. This, structure also provides a membrane-bound model of factor X.

1IOD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1IOD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb75_1.html Tissue Factor]]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IOD OCA].  

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