2nul: Difference between revisions

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{{STRUCTURE_2nul|  PDB=2nul  |  SCENE=  }}  
{{STRUCTURE_2nul|  PDB=2nul  |  SCENE=  }}  


'''PEPTIDYLPROLYL ISOMERASE FROM E. COLI'''
===PEPTIDYLPROLYL ISOMERASE FROM E. COLI===




==Overview==
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The structure of the unliganded form of the Escherichia coli cytoplasmic peptidyl-prolyl isomerase (ppiB gene product) in a new crystal form was determined by the molecular replacement method and refined to an R-factor of 16.1% at 2.1 A resolution. The enzyme crystallized in the orthorhombic C2221 space group with unit cell dimensions of a=44.7 A, b=68.2 A and c=102.0 A. Comparison with the reported structure of the enzyme complexed with the tripeptide substrate succinyl-Ala-Pro-Ala-p-nitroanilide revealed subtle changes that occur upon complex formation. There is evidence to suggest that two surface loops have significantly reduced mobility in the complexed structure.
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==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Rotamase]]
[[Category: Rotamase]]
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