2jnf: Difference between revisions

Revision as of 14:50, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2jnf.png

Template:STRUCTURE 2jnf

Solution structure of fly troponin C, isoform F1Solution structure of fly troponin C, isoform F1

Template:ABSTRACT PUBMED 17637342

About this StructureAbout this Structure

2JNF is a Single protein structure of sequence from Thermomicrobium roseum. Full experimental information is available from OCA.

ReferenceReference

The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles., De Nicola G, Burkart C, Qiu F, Agianian B, Labeit S, Martin S, Bullard B, Pastore A, Structure. 2007 Jul;15(7):813-24. PMID:17637342

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-'''Solution structure of fly troponin C, isoform F1'''
+===Solution structure of fly troponin C, isoform F1===
-==Overview==
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-To gain a molecular description of how muscles can be activated by mechanical stretch, we have solved the structure of the calcium-loaded F1 isoform of troponin C (TnC) from Lethocerus and characterized its interactions with troponin I (TnI). We show that the presence of only one calcium cation in the fourth EF hand motif is sufficient to induce an open conformation in the C-terminal lobe of F1 TnC, in contrast with what is observed in vertebrate muscle. This lobe interacts in a calcium-independent way both with the N terminus of TnI and, with lower affinity, with a region of TnI equivalent to the switch and inhibitory peptides of vertebrate muscles. Using both synthetic peptides and recombinant proteins, we show that the N lobe of F1 TnC is not engaged in interactions with TnI, excluding a regulatory role of this domain. These findings provide insights into mechanically stimulated muscle contraction.
+The line below this paragraph, {{ABSTRACT_PUBMED_17637342}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17637342 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_17637342}}
 ==About this Structure==
-JNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNF OCA].
+JNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNF OCA].
 ==Reference==
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 [[Category: Stretch activated muscle contraction]]
 [[Category: Troponin c]]
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