2j4z: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

@@ Line 1: / Line 1: @@
-[[Image:2j4z.jpg|left|200px]]
+{{Seed}}
+[[Image:2j4z.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2j4z|  PDB=2j4z  |  SCENE=  }}
-'''STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-680626'''
+===STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-680626===
-==Overview==
+<!--
-The optimization of a series of 5-phenylacetyl 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives toward the inhibition of Aurora kinases led to the identification of compound 9d. This is a potent inhibitor of Aurora kinases that also shows low nanomolar potency against additional anticancer kinase targets. Based on its high antiproliferative activity on different cancer cell lines, favorable chemico-physical and pharmacokinetic properties, and high efficacy in in vivo tumor models, compound 9d was ultimately selected for further development.
+The line below this paragraph, {{ABSTRACT_PUBMED_17125279}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17125279 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17125279}}
 ==About this Structure==
@@ Line 43: / Line 47: @@
 [[Category: Serine/threonine-protein kinase]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:20:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:14:23 2008''