2ixm: Difference between revisions

Revision as of 16:11, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2ixm.png

Template:STRUCTURE 2ixm

STRUCTURE OF HUMAN PTPASTRUCTURE OF HUMAN PTPA

Template:ABSTRACT PUBMED 16885030

About this StructureAbout this Structure

2IXM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity., Leulliot N, Vicentini G, Jordens J, Quevillon-Cheruel S, Schiltz M, Barford D, van Tilbeurgh H, Goris J, Mol Cell. 2006 Aug 4;23(3):413-24. PMID:16885030

Page seeded by OCA on Mon Jul 28 16:11:24 2008

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OCA

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-'''STRUCTURE OF HUMAN PTPA'''
+===STRUCTURE OF HUMAN PTPA===
-==Overview==
+<!--
-PTPA, an essential and specific activator of protein phosphatase 2A (PP2A), functions as a peptidyl prolyl isomerase (PPIase). We present here the crystal structures of human PTPA and of the two yeast orthologs (Ypa1 and Ypa2), revealing an all alpha-helical protein fold that is radically different from other PPIases. The protein is organized into two domains separated by a groove lined by highly conserved residues. To understand the molecular mechanism of PTPA activity, Ypa1 was cocrystallized with a proline-containing PPIase peptide substrate. In the complex, the peptide binds at the interface of a peptide-induced dimer interface. Conserved residues of the interdomain groove contribute to the peptide binding site and dimer interface. Structure-guided mutational studies showed that in vivo PTPA activity is influenced by mutations on the surface of the peptide binding pocket, the same mutations that also influenced the in vitro activation of PP2Ai and PPIase activity.
+The line below this paragraph, {{ABSTRACT_PUBMED_16885030}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16885030 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16885030}}
 ==About this Structure==
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 [[Category: Ppiase]]
 [[Category: Protein phosphatase 2a]]
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