2ijn: Difference between revisions

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OCA

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-[[Image:2ijn.gif|left|200px]]
+{{Seed}}
+[[Image:2ijn.png|left|200px]]
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 {{STRUCTURE_2ijn|  PDB=2ijn  |  SCENE=  }}
-'''Isothiazoles as active-site inhibitors of HCV NS5B polymerase'''
+===Isothiazoles as active-site inhibitors of HCV NS5B polymerase===
-==Overview==
+<!--
-Isothiazole analogs were discovered as a novel class of active-site inhibitors of HCV NS5B polymerase. The best compound has an IC(50) of 200 nM and EC(50) of 100 nM, which is a significant improvement over the starting inhibitor (1). The X-ray complex structure of 1 with HCV NS5B was obtained at a resolution of 2.2A, revealing that the inhibitor is covalently linked with Cys 366 of the 'primer-grip'. Furthermore, it makes considerable contacts with the C-terminus, beta-loop, and more importantly, to the active-site of the enzyme. The uniqueness of this binding mode offers a new insight for the rational design of novel inhibitors for HCV NS5B polymerase.
+The line below this paragraph, {{ABSTRACT_PUBMED_17049853}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17049853 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17049853}}
 ==About this Structure==
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 [[Category: Rdrp]]
 [[Category: Viral rna directed rna polymerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:34:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:08:48 2008''