1bc5: Difference between revisions
New page: left|200px<br /> <applet load="1bc5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bc5, resolution 2.2Å" /> '''CHEMOTAXIS RECEPTOR ... |
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==About this Structure== | ==About this Structure== | ||
1BC5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with CO, ACE and SAH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.80 2.1.1.80]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BC5 OCA]]. | 1BC5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with CO, ACE and SAH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Protein-glutamate_O-methyltransferase Protein-glutamate O-methyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.80 2.1.1.80]]. Structure known Active Site: COB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BC5 OCA]]. | ||
==Reference== | ==Reference== | ||
Chemotaxis receptor recognition by protein methyltransferase CheR., Djordjevic S, Stock AM, Nat Struct Biol. 1998 Jun;5(6):446-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628482 9628482] | Chemotaxis receptor recognition by protein methyltransferase CheR., Djordjevic S, Stock AM, Nat Struct Biol. 1998 Jun;5(6):446-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628482 9628482] | ||
[[Category: Protein-glutamate O-methyltransferase]] | |||
[[Category: Salmonella typhimurium]] | [[Category: Salmonella typhimurium]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: peptide binding]] | [[Category: peptide binding]] | ||
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Revision as of 13:15, 30 October 2007
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CHEMOTAXIS RECEPTOR RECOGNITION BY PROTEIN METHYLTRANSFERASE CHER
OverviewOverview
Signal transduction processes commonly involve reversible covalent, modifications of receptors. Bacterial chemotaxis receptors are reversibly, methylated at specific glutamate residues within coiled-coil regions of, their cytoplasmic domains. Methylation is catalyzed by an, S-adenosylmethionine-dependent protein methyltransferase, CheR, that binds, to a specific sequence at the C-termini of some chemotaxis receptors. From, this tethering point, CheR methylates neighboring receptor molecules. We, report the crystal structure, determined to 2.2 A resolution, of a complex, of the Salmonella typhimurium methyltransferase CheR bound to the, methylation reaction product, S-adenosylhomocysteine (AdoHcy), and the, C-terminal pentapeptide of the aspartate receptor, Tar. The structure, indicates ... [(full description)]
About this StructureAbout this Structure
1BC5 is a [Single protein] structure of sequence from [Salmonella typhimurium] with CO, ACE and SAH as [ligands]. Active as [Protein-glutamate O-methyltransferase], with EC number [2.1.1.80]. Structure known Active Site: COB. Full crystallographic information is available from [OCA].
ReferenceReference
Chemotaxis receptor recognition by protein methyltransferase CheR., Djordjevic S, Stock AM, Nat Struct Biol. 1998 Jun;5(6):446-50. PMID:9628482
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