2i9t: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2i9t.gif|left|200px]]
+{{Seed}}
+[[Image:2i9t.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2i9t|  PDB=2i9t  |  SCENE=  }}
-'''Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter'''
+===Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter===
-==Overview==
+<!--
-Upon viral infection, NF-kappaB translocates to the nucleus and activates the IFN-beta gene by binding to the PRDII element. Strikingly, NF-kappaB loses its ability to activate the IFN-beta gene when the PRDII element is substituted by closely related sites. We report here the crystal structure of NF-kappaB p50/p65 heterodimer bound to the PRDII element from the IFN-beta promoter. The structure reveals an unexpected alteration in configuration, in which the p50 specificity domain moves by as much as approximately 9 A when compared to NF-kappaB heterodimer bound to the immunoglobulin kappaB site (Ig-kappaB) while maintaining the same base-specific contacts with the DNA. Taken together, the structure offers new insights into the allosteric effects of closely related DNA sites on the configuration of NF-kappaB and its transcriptional selectivity.
+The line below this paragraph, {{ABSTRACT_PUBMED_12005436}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12005436 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12005436}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Thanos, D.]]
 [[Category: Protein-dna complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:14:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:04:20 2008''