2i40: Difference between revisions

Revision as of 00:51, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2i40.png

Template:STRUCTURE 2i40

Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitorCdk2/Cyclin A complexed with a thiophene carboxamide inhibitor

Template:ABSTRACT PUBMED 16997559

About this StructureAbout this Structure

2I40 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase., Bamborough P, Christopher JA, Cutler GJ, Dickson MC, Mellor GW, Morey JV, Patel CB, Shewchuk LM, Bioorg Med Chem Lett. 2006 Dec 15;16(24):6236-40. Epub 2006 Sep 25. PMID:16997559

Page seeded by OCA on Mon Jul 28 00:51:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor'''
+===Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor===
-==Overview==
+<!--
-The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-epsilon kinase is described. Compound 12e was identified with an IKK-epsilon enzyme potency of pIC(50) 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.
+The line below this paragraph, {{ABSTRACT_PUBMED_16997559}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16997559 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_16997559}}
 ==About this Structure==
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 [[Category: Cyclin]]
 [[Category: Kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:02:25 2008''
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