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| [[Image:2hn2.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2hn2| PDB=2hn2 | SCENE= }} | | {{STRUCTURE_2hn2| PDB=2hn2 | SCENE= }} |
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| '''Crystal structure of the CorA Mg2+ transporter homologue from T. maritima in complex with divalent cations'''
| | ===Crystal structure of the CorA Mg2+ transporter homologue from T. maritima in complex with divalent cations=== |
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| ==Overview==
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| We describe the CorA Mg(2+) transporter homologue from Thermotoga maritima in complex with 12 divalent cations at 3.7 A resolution. One metal is found near the universally conserved GMN motif, apparently stabilized within the transmembrane region. This portion of the selectivity filter might discriminate between the size and preferred coordination geometry of hydrated substrates. CorA may further achieve specificity by requiring the sequential dehydration of substrates along the length of its approximately 55 A long pore. Ten metal sites identified within the cytoplasmic funnel domain are linked to long extensions of the pore helices and regulate the transport status of CorA. We have characterized this region as an intrinsic divalent cation sensor and provide evidence that it functions as a Mg(2+)-specific homeostatic molecular switch. A proteolytic protection assay, biophysical data, and comparison to a soluble domain structure from Archaeoglobus fulgidus have revealed the potential reaction coordinate for this diverse family of transport proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16902408}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16902408 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16902408}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Integral membrane protein]] | | [[Category: Integral membrane protein]] |
| [[Category: Metal transporter protein]] | | [[Category: Metal transporter protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:28:43 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:12:02 2008'' |