2hm1: Difference between revisions

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[[Image:2hm1.gif|left|200px]]
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[[Image:2hm1.png|left|200px]]


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{{STRUCTURE_2hm1|  PDB=2hm1  |  SCENE=  }}  
{{STRUCTURE_2hm1|  PDB=2hm1  |  SCENE=  }}  


'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)'''
===Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)===




==Overview==
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We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown.
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{{ABSTRACT_PUBMED_17049233}}


==About this Structure==
==About this Structure==
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[[Category: Tomasselli, A G.]]
[[Category: Tomasselli, A G.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:26:38 2008''
 
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Revision as of 12:20, 27 July 2008

File:2hm1.png

Template:STRUCTURE 2hm1

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)

Template:ABSTRACT PUBMED 17049233

About this StructureAbout this Structure

2HM1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Design of potent inhibitors of human beta-secretase. Part 2., Freskos JN, Fobian YM, Benson TE, Moon JB, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):78-81. Epub 2006 Oct 4. PMID:17049233

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