2hde: Difference between revisions

Revision as of 11:12, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2hde.png

Template:STRUCTURE 2hde

Solution Structure of Human SAP18Solution Structure of Human SAP18

Template:ABSTRACT PUBMED 17002296

About this StructureAbout this Structure

2HDE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly., McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ, Biochemistry. 2006 Oct 3;45(39):11974-82. PMID:17002296

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2hde.jpg|left|200px]]
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 {{STRUCTURE_2hde|  PDB=2hde  |  SCENE=  }}
-'''Solution Structure of Human SAP18'''
+===Solution Structure of Human SAP18===
-==Overview==
+<!--
-Signal transduction pathways are frequently found to repress transcription of target genes in the absence of stimulation and, conversely, to upregulate transcription in the presence of a signal. Transcription factors are central in this dual regulatory mechanism and widely use a generalized mechanism to repress transcription through recruitment of a Sin3-histone deacetylase (HDAC) complex to their binding sites on DNA. The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. The solution structure of SAP18 reveals a ubiquitin-like fold with several large loop insertions relative to other family members. This fold supports the functional role of SAP18 as a protein-protein adapter module and provides insight for how SAP18 may bridge the Sin3-HDAC complex to transcription factors.
+The line below this paragraph, {{ABSTRACT_PUBMED_17002296}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17002296 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_17002296}}
 ==About this Structure==
-HDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDE OCA].
+HDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDE OCA].
 ==Reference==
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 [[Category: Sin3]]
 [[Category: Transcriptional repressor]]
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