2hcd: Difference between revisions

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-[[Image:2hcd.jpg|left|200px]]
+{{Seed}}
+[[Image:2hcd.png|left|200px]]
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 {{STRUCTURE_2hcd|  PDB=2hcd  |  SCENE=  }}
-'''Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide'''
+===Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide===
-==Overview==
+<!--
-The crystal structure of the ligand binding domain (LBD) of the wild-type Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist ligand with two identical side chains branching at carbon 20 reveals a ligand-dependent structural rearrangement of the ligand binding pocket (LBP). The rotation of a Leu side chain opens the access to a channel that can accommodate the second side chain of the ligand. The 25% increase of the LBP's volume does not alter the essential agonist features of VDR. The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands.
+The line below this paragraph, {{ABSTRACT_PUBMED_17218092}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17218092 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17218092}}
 ==About this Structure==
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 [[Category: Rochel, N.]]
 [[Category: Alpha helical sandwich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:07:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:51:01 2008''