2h2t: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2h2t.gif|left|200px]]
+{{Seed}}
+[[Image:2h2t.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2h2t|  PDB=2h2t  |  SCENE=  }}
-'''CD23 Lectin domain, Calcium 2+-bound'''
+===CD23 Lectin domain, Calcium 2+-bound===
-==Overview==
+<!--
-CD23, the low-affinity receptor for IgE (Fc epsilonRII), regulates IgE synthesis and also mediates IgE-dependent antigen transport and processing. CD23 is a unique Fc receptor belonging to the C-type lectin-like domain superfamily and binds IgE in an unusual, non-lectin-like manner, requiring calcium but not carbohydrate. We have solved the high-resolution crystal structures of the human CD23 lectin domain in the presence and absence of Ca2+. The crystal structures differ significantly from a previously determined NMR structure and show that calcium binding occurs at the principal binding site, but not at an auxiliary site that appears to be absent in human CD23. Conformational differences between the apo and Ca2+ bound structures suggest how IgE-Fc binding can be both calcium-dependent and carbohydrate-independent.
+The line below this paragraph, {{ABSTRACT_PUBMED_16765898}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16765898 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16765898}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Lectin domain]]
 [[Category: Low affinity ige receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:48:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:50:03 2008''