2h2s: Difference between revisions

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-[[Image:2h2s.gif|left|200px]]
+{{Seed}}
+[[Image:2h2s.png|left|200px]]
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 {{STRUCTURE_2h2s|  PDB=2h2s  |  SCENE=  }}
-'''Crystal Structure of E148A mutant of CLC-ec1 in SeCN-'''
+===Crystal Structure of E148A mutant of CLC-ec1 in SeCN-===
-==Overview==
+<!--
-CLC-ec1 is a bacterial archetype of CLC transporters, a ubiquitous class of proteins that catalyze transmembrane exchange of Cl- and H+ necessary for pH regulation of numerous physiological processes. Despite a profusion of high-resolution structures, the molecular mechanism of exchange remains unknown. Here, we rigorously demonstrate strict exchange stoichiometry of 2 Cl-/1 H+. In addition to Cl- and Br-, two non-halide ions, NO3- and SCN-, are shown to be transported by CLC-ec1, but with reduced H+ counter-transport. The loss of proton coupling to these anions is accompanied by an absence of bound anions in the central and external Cl- binding sites in the protein's anion selectivity region, as revealed by crystallographic comparison of Br- and SeCN- bound to this region.
+The line below this paragraph, {{ABSTRACT_PUBMED_16905147}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16905147 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16905147}}
 ==About this Structure==
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 [[Category: Clc]]
 [[Category: Transporter]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:48:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:26:09 2008''