2gv2: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2gv2.gif|left|200px]]
+{{Seed}}
+[[Image:2gv2.png|left|200px]]
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 {{STRUCTURE_2gv2|  PDB=2gv2  |  SCENE=  }}
-'''MDM2 in complex with an 8-mer p53 peptide analogue'''
+===MDM2 in complex with an 8-mer p53 peptide analogue===
-==Overview==
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-The most potent inhibitor of the p53-MDM2 interaction reported to date is an 8-mer p53 peptide analogue (Novartis peptide), which contains 6-chlorotryptophane (Cl-Trp) and phosphonomethylphenylalanine (Pmp) as key residues for the enhanced activity. We report here a crystal structure of the co-complex between MDM2 and the Novartis peptide solved at 1.8 A resolution. The structural basis for the role of the two aromatic residues are delineated by comparing the present structure with crystal structures of the MDM2 co-complex bound to other inhibitors including the wt-p53 peptide itself.
+The line below this paragraph, {{ABSTRACT_PUBMED_16925398}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16925398 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16925398}}
 ==About this Structure==
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 [[Category: Schubert, C.]]
 [[Category: Optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:34:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:05:59 2008''