2ged: Difference between revisions

Revision as of 03:59, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2ged.png

Template:STRUCTURE 2ged

Signal Recognition Particle Receptor Beta-Subunit in nucleotide-free dimerized formSignal Recognition Particle Receptor Beta-Subunit in nucleotide-free dimerized form

Template:ABSTRACT PUBMED 16627619

About this StructureAbout this Structure

2GED is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region., Schwartz TU, Schmidt D, Brohawn SG, Blobel G, Proc Natl Acad Sci U S A. 2006 May 2;103(18):6823-8. Epub 2006 Apr 20. PMID:16627619

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OCA

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-'''Signal Recognition Particle Receptor Beta-Subunit in nucleotide-free dimerized form'''
+===Signal Recognition Particle Receptor Beta-Subunit in nucleotide-free dimerized form===
-==Overview==
+<!--
-Protein translocation across and insertion into membranes is essential to all life forms. Signal peptide-bearing nascent polypeptide chains emerging from the ribosome are first sampled by the signal-recognition particle (SRP), then targeted to the membrane via the SRP receptor (SR), and, finally, transferred to the protein-conducting channel. In eukaryotes, this process is tightly controlled by the concerted action of three G proteins, the 54-kD subunit of SRP and the alpha- and beta-subunits of SR. We have determined the 2.2-A crystal structure of the nucleotide-free SRbeta domain. Unexpectedly, the structure is a homodimer with a highly intertwined interface made up of residues from the switch regions of the G domain. The remodeling of the switch regions does not resemble any of the known G protein switch mechanisms. Biochemical analysis confirms homodimerization in vitro, which is incompatible with SRalpha binding. The switch mechanism involves cis/trans isomerization of a strictly conserved proline, potentially implying a new layer of regulation of cotranslational transport.
+The line below this paragraph, {{ABSTRACT_PUBMED_16627619}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16627619}}
 ==About this Structure==
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 [[Category: Protein transport]]
 [[Category: Signal recognition particle]]
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