2gc8: Difference between revisions

Revision as of 02:07, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2gc8.png

Template:STRUCTURE 2gc8

Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b PolymeraseStructure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase

Template:ABSTRACT PUBMED 16722622

About this StructureAbout this Structure

2GC8 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

ReferenceReference

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site., Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS, J Med Chem. 2006 Jun 1;49(11):3052-5. PMID:16722622

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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+===Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase===
-==Overview==
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-Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity. The crystal structure of 6 and NS5b polymerase complex confirmed the binding near the active site region. The optimization approach and SAR are discussed in detail.
+The line below this paragraph, {{ABSTRACT_PUBMED_16722622}}, adds the Publication Abstract to the page
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