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| {{STRUCTURE_2gc4| PDB=2gc4 | SCENE= }} | | {{STRUCTURE_2gc4| PDB=2gc4 | SCENE= }} |
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| '''Structural comparison of the oxidized ternary electron transfer complex of methylamine dehydrogenase, amicyanin and cytochrome c551i from Paracoccus denitrificans with the substrate-reduced, copper free complex at 1.9 A resolution.'''
| | ===Structural comparison of the oxidized ternary electron transfer complex of methylamine dehydrogenase, amicyanin and cytochrome c551i from Paracoccus denitrificans with the substrate-reduced, copper free complex at 1.9 A resolution.=== |
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| ==Overview==
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| The crystal structure of a ternary protein complex has been determined at 2.4 angstrom resolution. The complex is composed of three electron transfer proteins from Paracoccus denitrificans, the quinoprotein methylamine dehydrogenase, the blue copper protein amicyanin, and the cytochrome c551i. The central region of the c551i is folded similarly to several small bacterial c-type cytochromes; there is a 45-residue extension at the amino terminus and a 25-residue extension at the carboxyl terminus. The methylamine dehydrogenase-amicyanin interface is largely hydrophobic, whereas the amicyanin-cytochrome interface is more polar, with several charged groups present on each surface. Analysis of the simplest electron transfer pathways between the redox partners points out the importance of other factors such as energetics in determining the electron transfer rates.
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| ==About this Structure== | | ==About this Structure== |
| 2GC4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC4 OCA]. | | 2GC4 is a 16 chains structure of sequences from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC4 OCA]. |
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| ==Reference== | | ==Reference== |
| Structure of an electron transfer complex: methylamine dehydrogenase, amicyanin, and cytochrome c551i., Chen L, Durley RC, Mathews FS, Davidson VL, Science. 1994 Apr 1;264(5155):86-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8140419 8140419]
| | <ref group="xtra">PMID:8140419</ref><references group="xtra"/> |
| [[Category: Amine dehydrogenase]] | | [[Category: Amine dehydrogenase]] |
| [[Category: Paracoccus denitrificans]] | | [[Category: Paracoccus denitrificans]] |
| [[Category: Protein complex]]
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| [[Category: Chen, Z.]] | | [[Category: Chen, Z.]] |
| [[Category: Davidson, V L.]] | | [[Category: Davidson, V L.]] |
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| [[Category: Electron transfer]] | | [[Category: Electron transfer]] |
| [[Category: Methylamine dehydrogenase]] | | [[Category: Methylamine dehydrogenase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:56:19 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:20:25 2009'' |