2fxu: Difference between revisions

Revision as of 21:05, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2fxu.png

Template:STRUCTURE 2fxu

X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.

Template:ABSTRACT PUBMED 16551075

About this StructureAbout this Structure

2FXU is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of bistramide A-actin complex at a 1.35 angstroms resolution., Rizvi SA, Tereshko V, Kossiakoff AA, Kozmin SA, J Am Chem Soc. 2006 Mar 29;128(12):3882-3. PMID:16551075

Page seeded by OCA on Mon Jul 28 21:05:51 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.'''
+===X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.===
-==Overview==
+<!--
-Bistramide A is a highly potent antiproliferative marine natural product from Lissoclinum bistratum. We have previously established actin as the primary cellular receptor of bistramide A. We report herein the X-ray structure of bistramide A bound to monomeric actin at a resolution of 1.35 A. The most notable aspect of the bistramide A-actin structure is an extensive hydrogen-bonding network established upon a deep penetration of the central segment of bistramide A into the actin-binding cleft between subdomains 1 and 3. The structure presents the first insight into the observed ability of bistramide A to modulate G-actin polymerization. The structural information combined with our ability to chemically modify the bistramide framework provides the basis for rational development of a series of new synthetic analogues as useful probes for studying actin cytoskeleton and as potential therapeutic leads.
+The line below this paragraph, {{ABSTRACT_PUBMED_16551075}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16551075}}
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 [[Category: Tereshko, V.]]
 [[Category: Actin complexed to bistramide some]]
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