2fp7: Difference between revisions

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{{STRUCTURE_2fp7|  PDB=2fp7  |  SCENE=  }}  
{{STRUCTURE_2fp7|  PDB=2fp7  |  SCENE=  }}  


'''West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H'''
===West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H===




==Overview==
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The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
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{{ABSTRACT_PUBMED_16532006}}


==About this Structure==
==About this Structure==
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[[Category: Ns3 protease]]
[[Category: Ns3 protease]]
[[Category: Substrate-based inhibitor]]
[[Category: Substrate-based inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:09:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:46:01 2008''

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