2fov: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2fov.gif|left|200px]]
+{{Seed}}
+[[Image:2fov.png|left|200px]]
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 {{STRUCTURE_2fov|  PDB=2fov  |  SCENE=  }}
-'''Human Carbonic Anhydrase II complexed with two-prong inhibitors'''
+===Human Carbonic Anhydrase II complexed with two-prong inhibitors===
-==Overview==
+<!--
-The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.
+The line below this paragraph, {{ABSTRACT_PUBMED_16506782}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16506782 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16506782}}
 ==Disease==
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 [[Category: Lyase]]
 [[Category: Zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:09:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:55:13 2008''