2fk0: Difference between revisions

Revision as of 02:51, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2fk0.png

Template:STRUCTURE 2fk0

Crystal Structure of a H5N1 influenza virus hemagglutinin.Crystal Structure of a H5N1 influenza virus hemagglutinin.

Template:ABSTRACT PUBMED 16543414

About this StructureAbout this Structure

2FK0 is a Protein complex structure of sequences from Viruses. Full crystallographic information is available from OCA.

ReferenceReference

Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:16543414

Page seeded by OCA on Mon Jul 28 02:51:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of a H5N1 influenza virus hemagglutinin.'''
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-==Overview==
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-The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.
+The line below this paragraph, {{ABSTRACT_PUBMED_16543414}}, adds the Publication Abstract to the page
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 [[Category: Membrane-fusion precursor]]
 [[Category: Virus/viral protein]]
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