2fde: Difference between revisions

Revision as of 05:07, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2fde.png

Template:STRUCTURE 2fde

Wild type HIV protease bound with GW0385Wild type HIV protease bound with GW0385

Template:ABSTRACT PUBMED 16458505

About this StructureAbout this Structure

2FDE is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385., Miller JF, Andrews CW, Brieger M, Furfine ES, Hale MR, Hanlon MH, Hazen RJ, Kaldor I, McLean EW, Reynolds D, Sammond DM, Spaltenstein A, Tung R, Turner EM, Xu RX, Sherrill RG, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1788-94. Epub 2006 Feb 3. PMID:16458505

Page seeded by OCA on Mon Jul 28 05:07:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2fde.gif|left|200px]]
+{{Seed}}
+[[Image:2fde.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2fde|  PDB=2fde  |  SCENE=  }}
-'''Wild type HIV protease bound with GW0385'''
+===Wild type HIV protease bound with GW0385===
-==Overview==
+<!--
-A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease inhibitor-resistant viruses. Optimization of the P1 moiety resulted in compounds with femtomolar enzyme activities and cellular antiviral activities in the low nanomolar range culminating in the identification of clinical candidate GW0385.
+The line below this paragraph, {{ABSTRACT_PUBMED_16458505}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16458505 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16458505}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Hiv protease]]
 [[Category: Inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:45:42 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:07:20 2008''