2f9g: Difference between revisions

Revision as of 14:58, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2f9g.png

Template:STRUCTURE 2f9g

Crystal structure of Fus3 phosphorylated on Tyr182Crystal structure of Fus3 phosphorylated on Tyr182

Template:ABSTRACT PUBMED 16424299

About this StructureAbout this Structure

2F9G is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway., Bhattacharyya RP, Remenyi A, Good MC, Bashor CJ, Falick AM, Lim WA, Science. 2006 Feb 10;311(5762):822-6. Epub 2006 Jan 19. PMID:16424299

Page seeded by OCA on Sun Jul 27 14:58:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of Fus3 phosphorylated on Tyr182'''
+===Crystal structure of Fus3 phosphorylated on Tyr182===
-==Overview==
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-Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly platforms. We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3. The resulting form of Fus3 is partially active-it is phosphorylated on only one of two key residues in the activation loop. Unexpectedly, at a systems level, autoactivated Fus3 appears to have a negative regulatory role, promoting Ste5 phosphorylation and a decrease in pathway transcriptional output. Thus, scaffolds not only direct basic pathway connectivity but can precisely tune quantitative pathway input-output properties.
+The line below this paragraph, {{ABSTRACT_PUBMED_16424299}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16424299}}
 ==About this Structure==
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 [[Category: Remenyi, A.]]
 [[Category: Map kinase]]
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