2f4v: Difference between revisions

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-[[Image:2f4v.gif|left|200px]]
+{{Seed}}
+[[Image:2f4v.png|left|200px]]
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 {{STRUCTURE_2f4v|  PDB=2f4v  |  SCENE=  }}
-'''30S ribosome + designer antibiotic'''
+===30S ribosome + designer antibiotic===
-==Overview==
+<!--
-The X-ray crystal structures for the complexes of three designer antibiotics, compounds 1, 2, and 3, bound to two models for the ribosomal aminoacyl-tRNA site (A site) at 2.5-3.0 Angstroms resolution and that of neamine at 2.8 Angstroms resolution are described. Furthermore, the complex of antibiotic 1 bound to the A site in the entire 30S ribosomal subunit of Thermus thermophilus is reported at 3.8 Angstroms resolution. Molecular dynamics simulations revealed that the designer compounds provide additional stability to bases A1492 and A1493 in their extrahelical forms. Snapshots from the simulations were used for free energy calculations, which revealed that van der Waals and hydrophobic effects were the driving forces behind the binding of designer antibiotic 3 when compared to the parental neamine.
+The line below this paragraph, {{ABSTRACT_PUBMED_16492561}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16492561 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16492561}}
 ==About this Structure==
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 [[Category: 30s ribosome subunit]]
 [[Category: Designer antibiotic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:27:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:01:21 2008''