2hck: Difference between revisions
New page: left|200px<br /> <applet load="2hck" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hck, resolution 3.0Å" /> '''SRC FAMILY KINASE HC... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2hck.gif|left|200px]]<br /> | [[Image:2hck.gif|left|200px]]<br /><applet load="2hck" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2hck" size=" | |||
caption="2hck, resolution 3.0Å" /> | caption="2hck, resolution 3.0Å" /> | ||
'''SRC FAMILY KINASE HCK-QUERCETIN COMPLEX'''<br /> | '''SRC FAMILY KINASE HCK-QUERCETIN COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the haematopoietic cell kinase Hck has been | The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases. | ||
==About this Structure== | ==About this Structure== | ||
2HCK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and QUE as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2HCK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb43_1.html Src Tyrosine Kinase]]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | 2HCK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=QUE:'>QUE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2HCK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb43_1.html Src Tyrosine Kinase]]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCK OCA]. | ||
==Reference== | ==Reference== | ||
| Line 27: | Line 26: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:40:27 2008'' | ||
Revision as of 18:40, 21 February 2008
|
SRC FAMILY KINASE HCK-QUERCETIN COMPLEX
OverviewOverview
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
About this StructureAbout this Structure
2HCK is a Single protein structure of sequence from Homo sapiens with and as ligands. The following page contains interesting information on the relation of 2HCK with [Src Tyrosine Kinase]. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658
Page seeded by OCA on Thu Feb 21 17:40:27 2008