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-[[Image:2du0.gif|left|200px]]
+{{Seed}}
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 {{STRUCTURE_2du0|  PDB=2du0  |  SCENE=  }}
-'''Crystal structure of basic winged bean lectin in complex with Alpha-D-galactose'''
+===Crystal structure of basic winged bean lectin in complex with Alpha-D-galactose===
-==Overview==
+<!--
-The crystal structure of the complexes of basic winged-bean lectin with galactose, 2-methoxygalactose, N-acetylgalactosamine and methyl-alpha-N-acetylgalactosamine have been determined. Lectin-sugar interactions involve four hydrogen bonds and a stacking interaction in all of the complexes. In addition, an N-H...O hydrogen bond involving the hydroxyl group at C2 exists in the galactose and 2-methoxygalactose complexes. An additional hydrophobic interaction involving the methyl group in the latter leads to the higher affinity of the methyl derivative. In the lectin-N-acetylgalactosamine complex the N-H...O hydrogen bond is lost, but a compensatory hydrogen bond is formed involving the O atom of the acetamido group. In addition, the CH(3) moiety of the acetamido group is involved in hydrophobic interactions. Consequently, the 2-methyl and acetamido derivatives of galactose have nearly the same affinity for the lectin. The methyl group alpha-linked to the galactose takes part in additional hydrophobic interactions. Therefore, methyl-alpha-N-acetylgalactosamine has a higher affinity than N-acetylgalactosamine for the lectin. The structures of basic winged-bean lectin-sugar complexes provide a framework for examining the relative affinity of galactose and galactosamine for the lectins that bind to them. The complexes also lead to a structural explanation for the blood-group specificity of basic winged-bean lectin.
+The line below this paragraph, {{ABSTRACT_PUBMED_17057334}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17057334 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17057334}}
 ==About this Structure==
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 ==Reference==
 Structural basis for the carbohydrate-specificity of basic winged-bean lectin and its differential affinity for Gal and GalNAc., Kulkarni KA, Katiyar S, Surolia A, Vijayan M, Suguna K, Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1319-24. Epub 2006, Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057334 17057334]
+Carbohydrate specificity and quaternary association in basic winged bean lectin: X-ray analysis of the lectin at 2.5 A resolution., Prabu MM, Sankaranarayanan R, Puri KD, Sharma V, Surolia A, Vijayan M, Suguna K, J Mol Biol. 1998 Mar 6;276(4):787-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9500920 9500920]
+Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: a crystallographic, thermodynamic and modelling study., Kulkarni KA, Sinha S, Katiyar S, Surolia A, Vijayan M, Suguna K, FEBS Lett. 2005 Dec 19;579(30):6775-80. Epub 2005 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16310781 16310781]
+Structure of basic winged-bean lectin and a comparison with its saccharide-bound form., Manoj N, Srinivas VR, Suguna K, Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):794-800. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10089310 10089310]
 [[Category: Psophocarpus tetragonolobus]]
 [[Category: Single protein]]
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 [[Category: Glycosylated protein]]
 [[Category: Legume lectin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:22:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:33:25 2008''