2dq7: Difference between revisions

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-[[Image:2dq7.gif|left|200px]]
+{{Seed}}
+[[Image:2dq7.png|left|200px]]
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 {{STRUCTURE_2dq7|  PDB=2dq7  |  SCENE=  }}
-'''Crystal Structure of Fyn kinase domain complexed with staurosporine'''
+===Crystal Structure of Fyn kinase domain complexed with staurosporine===
-==Overview==
+<!--
-The tyrosine kinase Fyn is a member of the Src kinase family. Besides the role of Fyn in T cell signal transduction in concert with Lck, its excess activity in the brain is involved with conditions such as Alzheimer's and Parkinson's diseases. Therefore, inhibition of Fyn kinase may help counteract these nervous system disorders. Here, we solved the crystal structure of the human Fyn kinase domain complexed with staurosporine, a potent kinase inhibitor, at 2.8 A resolution. Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes. The small structural differences in the staurosporine-binding and/or -unbinding region among the three kinase domains may help obtaining the selective inhibitors against the respective kinases.
+The line below this paragraph, {{ABSTRACT_PUBMED_16782058}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16782058 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16782058}}
 ==About this Structure==
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 [[Category: Src family]]
 [[Category: Staurosporine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 00:57:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:58:13 2008''