2d10: Difference between revisions

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-[[Image:2d10.gif|left|200px]]
+{{Seed}}
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 {{STRUCTURE_2d10|  PDB=2d10  |  SCENE=  }}
-'''Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide'''
+===Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide===
-==Overview==
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-The Na+/H+ exchanger regulatory factor (NHERF) is a key adaptor protein involved in the anchoring of ion channels and receptors to the actin cytoskeleton through binding to ERM (ezrin/radixin/moesin) proteins. NHERF binds the FERM domain of ERM proteins, although NHERF has no signature Motif-1 sequence for FERM binding found in adhesion molecules. The crystal structures of the radixin FERM domain complexed with the NHERF-1 and NHERF-2 C-terminal peptides revealed a peptide binding site of the FERM domain specific for the 13 residue motif MDWxxxxx(L/I)Fxx(L/F) (Motif-2), which is distinct from Motif-1. This Motif-2 forms an amphipathic alpha helix for hydrophobic docking to subdomain C of the FERM domain. This docking causes induced-fit conformational changes in subdomain C and affects binding to adhesion molecule peptides, while the two binding sites are not overlapped. Our studies provide structural paradigms for versatile ERM linkages between membrane proteins and the cytoskeleton.
+The line below this paragraph, {{ABSTRACT_PUBMED_16615918}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16615918 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_16615918}}
 ==About this Structure==
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 ==Reference==
 Structural basis for NHERF recognition by ERM proteins., Terawaki S, Maesaki R, Hakoshima T, Structure. 2006 Apr;14(4):777-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16615918 16615918]
+Crystallographic characterization of the radixin FERM domain bound to the C-terminal region of the human Na+/H+-exchanger regulatory factor (NHERF)., Terawaki S, Maesaki R, Okada K, Hakoshima T, Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):177-9. Epub 2002, Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12499563 12499563]
+Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain., Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T, EMBO J. 2000 Sep 1;19(17):4449-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10970839 10970839]
+Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex., Hamada K, Shimizu T, Yonemura S, Tsukita S, Tsukita S, Hakoshima T, EMBO J. 2003 Feb 3;22(3):502-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12554651 12554651]
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
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 [[Category: Terawaki, S.]]
 [[Category: Protein-peptide complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:29:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:58:48 2008''