2bqv: Difference between revisions

Revision as of 11:08, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2bqv.png

Template:STRUCTURE 2bqv

HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455

Template:ABSTRACT PUBMED 16335934

About this StructureAbout this Structure

2BQV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold., Ekegren JK, Unge T, Safa MZ, Wallberg H, Samuelsson B, Hallberg A, J Med Chem. 2005 Dec 15;48(25):8098-102. PMID:16335934

Page seeded by OCA on Mon Jul 28 11:07:54 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455'''
+===HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455===
-==Overview==
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-Novel HIV-1 protease inhibitors encompassing a tertiary alcohol as part of the transition-state mimicking unit have been synthesized. Variation of the P1'-P3' residues and alteration of the tertiary alcohol absolute stereochemistry afforded 10 inhibitors. High potencies for the compounds with (S)-configuration at the carbon carrying the tertiary hydroxyl group were achieved with Ki values down to 2.4 nM. X-ray crystallographic data for a representative compound in complex with HIV-1 protease are presented.
+The line below this paragraph, {{ABSTRACT_PUBMED_16335934}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16335934}}
 ==About this Structure==
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 [[Category: Hydrolase complex]]
 [[Category: Inhibitor]]
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