2bpy: Difference between revisions

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{{STRUCTURE_2bpy|  PDB=2bpy  |  SCENE=  }}  
{{STRUCTURE_2bpy|  PDB=2bpy  |  SCENE=  }}  


'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''
===HIV-1 PROTEASE-INHIBITOR COMPLEX===




==Overview==
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The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affords a fast turnaround of structural information for iterative rational drug designs and obviates the need for studying the complex structures by co-crystallization. The replacement approach has been successfully used with single crystals of the HIV-1 protease complexed with a weak inhibitor. The structures of the complexes obtained by the replacement method are similar to those determined by co-crystallization.
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{{ABSTRACT_PUBMED_9757136}}


==About this Structure==
==About this Structure==
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[[Category: Acid protease]]
[[Category: Acid protease]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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