2bid: Difference between revisions

Revision as of 00:29, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2bid.png

Template:STRUCTURE 2bid

HUMAN PRO-APOPTOTIC PROTEIN BIDHUMAN PRO-APOPTOTIC PROTEIN BID

Template:ABSTRACT PUBMED 10089877

About this StructureAbout this Structure

2BID is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Solution structure of BID, an intracellular amplifier of apoptotic signaling., Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G, Cell. 1999 Mar 5;96(5):615-24. PMID:10089877

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OCA

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-'''HUMAN PRO-APOPTOTIC PROTEIN BID'''
+===HUMAN PRO-APOPTOTIC PROTEIN BID===
-==Overview==
+<!--
-We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage. BID contains eight alpha helices where two central hydrophobic helices are surrounded by six amphipathic ones. The fold resembles poreforming bacterial toxins and shows similarity to BCL-XL although sequence homology to BCL-XL is limited to the 16-residue BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex. Additionally, we show that the overall structure of BID is preserved after cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent and -independent modes of action in inducing mitochondrial damage.
+The line below this paragraph, {{ABSTRACT_PUBMED_10089877}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10089877 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_10089877}}
 ==About this Structure==
-BID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA].
+BID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA].
 ==Reference==
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 [[Category: Apoptosis regulation and amplification]]
 [[Category: Programmed cell death]]
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