2bfq: Difference between revisions

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-[[Image:2bfq.gif|left|200px]]
+{{Seed}}
+[[Image:2bfq.png|left|200px]]
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 {{STRUCTURE_2bfq|  PDB=2bfq  |  SCENE=  }}
-'''MACRO DOMAINS ARE ADP-RIBOSE BINDING MOLECULES'''
+===MACRO DOMAINS ARE ADP-RIBOSE BINDING MOLECULES===
-==Overview==
+<!--
-The ADP-ribosylation of proteins is an important post-translational modification that occurs in a variety of biological processes, including DNA repair, transcription, chromatin biology and long-term memory formation. Yet no protein modules are known that specifically recognize the ADP-ribose nucleotide. We provide biochemical and structural evidence that macro domains are high-affinity ADP-ribose binding modules. Our structural analysis reveals a conserved ligand binding pocket among the macro domain fold. Consistently, distinct human macro domains retain their ability to bind ADP-ribose. In addition, some macro domain proteins also recognize poly-ADP-ribose as a ligand. Our data suggest an important role for proteins containing macro domains in the biology of ADP-ribose.
+The line below this paragraph, {{ABSTRACT_PUBMED_15902274}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15902274 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15902274}}
 ==About this Structure==
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 [[Category: Macro_h2a domain/hydrolase]]
 [[Category: Nucleotide]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:13:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:45:02 2008''