2b5i: Difference between revisions

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[[Image:2b5i.gif|left|200px]]
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{{STRUCTURE_2b5i|  PDB=2b5i  |  SCENE=  }}  
{{STRUCTURE_2b5i|  PDB=2b5i  |  SCENE=  }}  


'''cytokine receptor complex'''
===cytokine receptor complex===




==Overview==
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Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics.
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{{ABSTRACT_PUBMED_16293754}}


==Disease==
==Disease==
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[[Category: Fibronectin domain]]
[[Category: Fibronectin domain]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:52:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:16:26 2008''

Revision as of 20:16, 28 July 2008

File:2b5i.png

Template:STRUCTURE 2b5i

cytokine receptor complexcytokine receptor complex

Template:ABSTRACT PUBMED 16293754

DiseaseDisease

Known disease associated with this structure: Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680], Combined immunodeficiency, X-linked, moderate OMIM:[308380], Severe combined immunodeficiency, X-linked OMIM:[308380], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[147730], Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[147730]

About this StructureAbout this Structure

2B5I is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors., Wang X, Rickert M, Garcia KC, Science. 2005 Nov 18;310(5751):1159-63. PMID:16293754

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