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| [[Image:2b3x.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2b3x| PDB=2b3x | SCENE= }} | | {{STRUCTURE_2b3x| PDB=2b3x | SCENE= }} |
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| '''Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)'''
| | ===Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)=== |
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| ==Overview==
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| Iron regulatory proteins (IRPs) control the translation of proteins involved in iron uptake, storage and utilization by binding to specific noncoding sequences of the corresponding mRNAs known as iron-responsive elements (IREs). This strong interaction assures proper iron homeostasis in animal cells under iron shortage. Conversely, under iron-replete conditions, IRP1 binds a [4Fe-4S] cluster and functions as cytosolic aconitase. Regulation of the balance between the two IRP1 activities is complex, and it does not depend only on iron availability. Here, we report the crystal structure of human IRP1 in its aconitase form. Comparison with known structures of homologous enzymes reveals well-conserved folds and active site environments with significantly different surface shapes and charge distributions. The specific features of human IRP1 allow us to propose a tentative model of an IRP1-IRE complex that agrees with a range of previously obtained data.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16407072}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16407072 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16407072}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Volbeda, A.]] | | [[Category: Volbeda, A.]] |
| [[Category: Irp1 ire-irp1 aconitase activity]] | | [[Category: Irp1 ire-irp1 aconitase activity]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:49:28 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:44:39 2008'' |