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| [[Image:2a94.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2a94| PDB=2a94 | SCENE= }} | | {{STRUCTURE_2a94| PDB=2a94 | SCENE= }} |
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| '''Structure of Plasmodium falciparum lactate dehydrogenase complexed to APADH.'''
| | ===Structure of Plasmodium falciparum lactate dehydrogenase complexed to APADH.=== |
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| ==Overview==
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| Malaria caused by Plasmodium vivax is a major cause of global morbidity and, in rare cases, mortality. Lactate dehydrogenase is an essential Plasmodium protein and, therefore, a potential antimalarial drug target. Ideally, drugs directed against this target would be effective against both major species of Plasmodium, P. falciparum and P. vivax. In this study, the crystal structure of the lactate dehydrogenase protein from P. vivax has been solved and is compared to the equivalent structure from the P. falciparum enzyme. The active sites and cofactor binding pockets of both enzymes are found to be highly similar and differentiate these enzymes from their human counterparts. These structures suggest effective inhibition of both enzymes should be readily achievable with a common inhibitor. The crystal structures of both enzymes have also been solved in complex with the synthetic cofactor APADH. The unusual cofactor binding site in these Plasmodium enzymes is found to readily accommodate both NADH and APADH, explaining why the Plasmodium enzymes retain enzymatic activity in the presence of this synthetic cofactor.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16331982}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16331982 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16331982}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Turgut-Balik, D.]] | | [[Category: Turgut-Balik, D.]] |
| [[Category: Rossmann fold]] | | [[Category: Rossmann fold]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:45:57 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:16:14 2008'' |